People with persistent pain symptoms often receive mixed messages about what treatments are the safest and most effective. They also question why their symptoms have persisted, and if there is anything they can do to improve their circumstances. Please see below for the most up-to-date answers to these questions.

Questions

Frequently Asked Questions

What is pain?
What can I do to improve my symptoms?
What treatments are safest/most effective?
What causes pain to become chronic?
How long does it usually take to get better?
Will exercise make my pain worse?
Did I do something wrong to cause my pain?
Is my pain all in my head?
How do I communicate my pain to my doctor?
What treatments should I avoid?
Will surgery help my pain?
Will persistent pain cause mental health issues?
How do I support someone with persistent pain?
How do I know if my pain is dangerous?
Are there any promising treatments for my pain?
What is a pain flare, and how do I manage it?
What if I no longer have access to opioids?
My question is not listed. 
What is pain?

     An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage.

  • Pain is always a personal experience that is influenced to varying degrees by biological, psychological, and social factors.
  • Pain and nociception are different phenomena. Pain cannot be inferred solely from activity in sensory neurons.
  • Through their life experiences, individuals learn the concept of pain.
  • A person’s report of an experience as pain should be respected.
  • Although pain usually serves an adaptive role, it may have adverse effects on function and social and psychological well-being.
  • Verbal description is only one of several behaviors to express pain; inability to communicate does not negate the possibility that a human or a nonhuman animal experiences pain.

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What causes pain to become chronic?

    In short, we don't really know for sure. There is very strong evidence to suggest that our emotional appraisal of the environment is the strongest predictor or pain chronification, but there are additional factors which may contribute. Read more below. Of note, it is suspected that pain resolution mechanisms are strongly linked to our immune system. 

 

    Chronic pain, defined as pain lasting longer than 3 months, can result from a variety of factors, including injury, disease, nerve damage, or even unknown causes. The pain can persist even after the underlying cause has been addressed or healed, and it can have a significant impact on a person's quality of life. 

    Here's a more detailed look at possible contributors to the development of chronic pain:

 

1. Initial Injury or Underlying Conditions:

 

Nerve Damage:

    Damage to nerves, also known as neuropathy, has the potential to alter the function of those nerves where they may be overactive, underactive, or act unpredictably.

 

Spinal Issues:

    Conditions like herniated discs or stenosis have the potential to contribute to pain. Keep in mind, however, these conditions may also be present in people without any pain whatsoever. 

 

Trauma and Injuries:

    An initial injury, like a back sprain or pulled muscle, can sometimes lead to ongoing pain if there is actual damage to the nerves (see above) where the nerves no longer function properly, or when other factors (poor sleep quality/quantity, unmanaged stress, use of tobacco or alcohol, illicit drug use, lack of social support/validation).

 

Chronic Diseases:

    Autoimmune disorders, and conditions like osteoarthritis, fibromyalgia, and some types of cancer may contribute to ongoing pain symptoms.

 

2. Nerve Sensitization and Central Sensitization:

 

Nociception:

    Nociception is the process by which mechanical, chemical or thermal stimuli / changes are detected (unconsciously) and transmitted via slow nerve fibers to the spinal cord and eventually the thalamus in the brain. When ongoing nociception is present, the nervous system can become more sensitive, even to completely harmless stimuli. 

 

Pain System Hypersensitivity:

    This is a state of heightened excitability in the central nervous system (brain and spinal cord) that leads to increased sensitivity to mechanical, chemical and thermal stimuli, in addition to other sensory stimuli. It's characterized by a reduction in pain threshold and an amplification of pain responses, even in areas not directly affected by injury. This can result in the brain producing pain in areas where it isn't necessary, or a normal touch sensation being perceived as painful. 

 

3. Psychological Factors:

    Stress and Anxiety: Chronic pain can be exacerbated by stress, anxiety, and depression, and these mental health conditions can also contribute to the development of chronic pain. 

 

4. Adverse Childhood Experiences:

    Childhood adverse experiences have long been identified as a source of persistent vulnerability to the development of persistent pain, anxiety, depression, PTSD and other conditions. (Learn more)

 

5. Unknown Causes:

    In some cases, the cause of chronic pain may not be obvious, even after extensive testing. 

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What can I do to improve my symptoms?

    (Credit: US Pain Foundation)  In conjunction with traditional pain management, there are a number of self-management strategies that can help reduce pain levels and improve your quality of life. Don’t underestimate your ability to have an impact on your health and pain levels!

    Here are some areas where lifestyle changes can help improve pain:

 

Activity modification

    Restricting or modifying your activities may seem obvious, but it can be difficult to adjust when you’re used to being able to do certain things a certain way. It can take many years of trial and error to identify your body’s limitations and specific triggers for pain, and then to find strategies to work with or around them. Be patient with yourself as you explore your body’s limits—and abilities.

    You will need to determine what your limitations are, but perhaps it’s that you need to lie down for 10 minutes every two hours. Or maybe you find you can go for a 30-minute walk, but you need to allow 30 minutes of rest before and afterward. Perhaps you need a standing desk instead of a seated one to work at your computer comfortably. As you get to know your body, keep in mind there is a fine balance between getting appropriate rest and recuperation—and keeping up your strength, mobility, and stamina as much as possible. Don’t be afraid to get creative with accommodating your body’s needs. Investigate assistive devices, like braces or mobility tools, such as canes. Consider adaptive technology, too. For example, if typing on a computer is challenging, you may want to look into dictation software.

    Occupational therapists can be very helpful in coming up with solutions for keeping up with your daily activities and continuing to do the things you enjoy. If you work, ask your manager about getting an assessment from an ergonomics specialist. Remember that you have a right to reasonable accommodations for your health in the workplace. 

 

Exercise

As difficult as it is to get yourself moving when you have chronic pain, it’s also extremely important. Here are four key reasons to get moving:

  • Maintaining a healthy weight - Excess body weight puts extra strain on your joints, muscles and organs.
  • Cardiovascular health - Too little activity can result in disabling cardiovascular conditions, from orthostatic intolerance to heart disease. Your body already has enough to deal with chronic pain – don’t add heart, circulation, and lung problems to the list!
  • Strength, flexibility, and stamina - Chronic pain can negatively impact your strength, flexibility, and stamina, which in turn increase your pain and level of disability.
  • Endorphins - Aerobic exercise produces endorphins, the feel-good chemicals that act as your body’s natural painkillers. Start small and increase the intensity of your workout as your body allows. Remember that any exercise is better than nothing at all; just do the best you can.

 

Here are some ideas for exercise to get you started:

  •  Yoga or tai chi - Some types of yoga are directly tailored to individuals who have physical limitations. Try searching for a YouTube video for “Restorative yoga,” or “chair yoga.” Tai chi is also a fabulous, gentle way to encourage flexibility and stability.
  • Aquatic exercise - Pool therapy is great for those with musculoskeletal problems. It provides a gentle, low-impact way to get a workout. You can try your own exercises, find a group class, or a physical therapist who specializes in designing one-on-one aquatic exercises. Some pools are heated, to make it even easier on your joints and muscles.
  • Short walks - Even a short walk is good! Turn on your headphones and listen to a podcast or audiobook to help distract and encourage yourself.
  • Short bursts of cardio - Science has shown that even one minute of all-out exercise has benefits. The key is to get your heart rate up and your blood bumping. Start small with a few minutes of exercise and build up slowly. Chronic pain-friendly cardio ideas include using reclining bikes and elliptical machines.
  • Please note: we recommend checking with a clinician before beginning any exercise program to ensure it is safe for you. 

 

Diet and nutrition

    A thoughtful, balanced diet is key to maintaining a healthy weight, reducing inflammation, and getting important nutrients that support your overall well-being. Some people find that certain types of diets lessen their pain, such as an anti-inflammatory diet; a vegetarian or vegan diet; a paleo diet; a gluten-free diet; and so on. Explore different diets to find out what works for you. Regardless of whether you follow a specific set of guidelines surrounding food, here are some key principles that hold true:

  • Eat as many fresh vegetables and fruits as humanly possible.
  • Limit extremely sugary and processed foods.
  • Avoid foods with “bad” fats, like trans fats and saturated fats.
  • Eat more foods that have “good” fats, like fish, avocados, nuts, and olive oil.
  • Stay hydrated. The Institute of Medicine recommends 7 liters (15 cups) for the average adult male and 2.7 liters (11 cups) for the average adult female.
  • If you’re interested in extra help with your diet, consider meeting with a licensed nutritionist. 

 

Sleep

    An estimated 50 percent to percent of people with chronic pain have ongoing sleep difficulties. Studies show that inadequate sleep, however, can exacerbate pain. Here are some tips for ensuring you get a good night’s rest despite pain.

  • Establish a routine. Going to bed and waking up at the same time every day—even on the weekends—reinforces the natural sleep-wake cycle in your body. You can also help reinforce bedtime by establishing a wind-down routine, e.g. by taking a bath, meditating, reading or listening to soothing music.
  • Create a restful environment. Turn on white noise, use ear plugs, invest in comfortable bedding, and keep the room temperature cool. Exposure to light is especially important: dim or turn off the lights in your house 30 to 60 minutes before going to bed. The light from cell phone and TV screens can also interfere with circadian rhythms, so shut down all devices as you prepare for bed.
  • Watch what you eat and drink. Caffeinated products — like tea or coffee, chocolate — anything containing nicotine, or any other stimulants should be avoided for at least four to six hours before you plan to go to sleep. Even alcohol, which initially makes you feel tired, makes it harder to get high-quality sleepy. Furthermore, heavy meals and too many fluids before bed might keep you up because you are uncomfortable or need to use the bathroom.
  • Get tired! Napping during the day can interfere with sleep at night. If you must, limit your snooze to 30 minutes, and give yourself at least four hours between the nap and bedtime. In addition, exercising during the day helps tire out your body and can foster better sleep at night. Try to work out at least a few hours before bed, if possible.
  • Still struggling? Ask your doctor about meeting with a sleep specialist.

 

Reduce stress

    Pain increases stress, and stress increases pain. But you can break this cycle by proactively trying to reduce stress wherever possible. Multiple studies have shown that reducing stress and relaxation techniques can improve overall health and well-being, and may even reduce pain or improve the perception of pain.

    Some examples of stress reduction techniques and strategies include:

  • Meditation
  • Relaxation techniques such as breathing exercises, progressive muscle relaxation, visual imagery, and mindfulness
  • Music, art or dance therapy
  • Journaling
  • Exercise
  • Support groups
  • Counseling and cognitive behavioral therapy
  • Generally speaking, reducing stress with chronic pain also requires:
  • Pacing yourself to allow for sufficient rest and recovery;
  • Learning to say no and putting your health first;
  • Focusing on the things you can do and not what you can’t;
  • Communicating clearly with your loved ones about your needs and challenges;
  • Letting go of guilt and shame surrounding pain.

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How long does it usually take to get better?

    Recovery from chronic pain, which is defined as pain that persists longer than three months, involves a combination of strategies, not a single cure. Recovery timeframes vary from person to person and are dependent on how well we are able to address all of the contributing factors to why pain symtoms persist. Key approaches include an interdisciplinary team of healthcare professionals, physical activity and exercise, stress management through mindfulness and relaxation, and strategies for pacing and managing energy levels. Structured, interdisciplinary programs with a focus on recovery, pain science education, and support networks are also crucial for improving function and reducing the impact of chronic pain on daily life. 

 

Key Components of Chronic Pain Recovery

  • Medical and Therapies:
    • Inter- and Transdisciplinary Programs: Intensive, team-based programs combining physical therapy, cognitive behavioral therapy, and medication management.
    • Physical Therapy: Therapists use education, motivation and empowerment strategies to improve function and self-efficacy. They use graded exposure, progressive desensitization and targeted exercise to improve strength, flexibility, and mobility while also providing education on pain science.
  • Mind-Body Techniques: Practices like mindfulness, meditation, yoga, tai chi, and deep breathing help manage stress, reduce muscle tension, and improve conscious control over the nervous system's response to pain. 
  • Lifestyle and Coping Strategies:
    • Physical Activity: Regular, moderate-intensity exercise is vital for building strength, improving flexibility, and releasing endorphins, the body's natural pain relievers.

    • Pacing: Learning to balance physical and mental tasks by setting realistic goals, taking regular breaks, and moderating daily activities to avoid overexertion.
    • Support Systems: Engaging with support networks provides emotional support, shared experiences, and encouragement.
    • Mindfulness and Relaxation: Structured practice to "dial down" the body's danger-sensing signals and calm the nervous system. 
  • Education:
    • Pain Science Education (PSE): Understanding the biological basis of pain and the nervous system's role can reduce fear and facilitate better movement and recovery. 

 

Important Considerations:

  • Acknowledge and Understand Your Pain: Chronic pain is a complex condition with both physical and psychological components, and understanding its specific impact on you is the first step toward recovery. 
  • No Single Cure: Recovery is an ongoing process requiring a team approach and a combination of strategies tailored to your individual needs. 
  • Focus on Function: The goal is often to regain function and reduce the limitations that chronic pain imposes on daily activities. 

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What treatments are safe/most effective?

    Effective treatments include a combination of non-opioid medications (like NSAIDs, antidepressants, and antiseizure drugs), physical and psychological therapies (such as physical therapy, exercise, and cognitive behavioral therapy), and other modalities like acupuncture/acupressure. A personalized treatment plan, often including lifestyle changes and active patient participation, is key to recovery with from persistent pain. 

 

Medications
    Non-opioid medications are often the first line of treatment for chronic pain and may include: 

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Such as ibuprofen or naproxen, to reduce pain and inflammation. 
  • Antidepressants: Some types, like tricyclic antidepressants and SNRIs, can help manage chronic pain and co-existing depression. 
  • Antiseizure Medications: Drugs like gabapentin and pregabalin may be used to treat certain types of chronic pain. 
  • Topical Analgesics: Creams containing lidocaine or capsaicin can provide localized pain relief. 

 

Therapies
    Non-drug therapies are crucial for active patient participation and can improve overall functioning: 

  • Physical Therapy: Involves exercises and techniques to improve confidence, self-efficacy, understanding of pain science, and overall function. 
  • Exercise Therapy: Including aerobic, resistance, and aquatic exercises, can provide health benefits and relieve symptoms. 
  • Mind-Body Practices: Yoga, tai chi, and mindfulness-based stress reduction can help manage pain and stress. 
  • Cognitive Behavioral Therapy (CBT): A psychological treatment that helps individuals change negative thought patterns and behaviors related to pain. 
  • Acupuncture: A traditional therapy that has shown effectiveness in managing chronic pain, including back and pelvic pain. 
  • Massage Therapy: Can provide relief to areas of muscle pain and inflammation. 

 

Lifestyle Changes and Other Treatments

  • Weight Loss: Can help prevent or reduce pain symptoms. 
  • Multimodal Approach: Combining several of these treatments is often more effective than relying on a single therapy. 

 

Important Considerations

  • Personalized Treatment: The most effective treatment depends on the specific type of chronic pain and the individual's needs. 
  • Active Patient Participation: Engaging in active treatments and lifestyle changes is essential for managing chronic pain. 
  • Consult a Healthcare Provider: A doctor can provide guidance on which medications and treatments are appropriate for your condition and monitor for side effects. 

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Will exercise make my pain worse?

    (Source) Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial pain. Regular physical activity is recommended for treatment of chronic pain and its effectiveness has been established in clinical trials for people with a variety of pain conditions. 

    Exercise can make your pain worse if you do too much too soon after doing too little for too long. However, for many people with chronic pain, moderate, guided exercise actually helps reduce pain by improving circulation, lubricating joints, reducing inflammation, and releasing endorphins. It's crucial to start slowly, listen to your body, choose appropriate activities, and consult a healthcare professional to avoid exacerbating your condition. 

 

    When exercise can make pain worse:

  • Overdoing it: Rushing into strenuous activity can lead to soreness, fatigue, and overuse. 
  • High-impact activities if introduced too quickly: Exercises like running, step aerobics, and high-intensity training can put excessive stress on the body and worsen pain if introduced too quickly. 
  • Not consulting a professional: Before starting an exercise program, especially for chronic pain, it's vital to get clearance from your doctor. 

 

    How exercise can help relieve pain:

  • Boosts mood: Exercise releases endorphins and other mood-boosting chemicals that can reduce the perception of pain and improve overall well-being. 
  • Improves joint health:  Physical activity lubricates and improves the health and function of joints, helping to reduce stiffness and pain. 
  • Reduces inflammation: Regular movement can help decrease swelling and inflammation in the body. 
  • Enhances circulation: Increased blood flow benefits your overall health and can help with pain management. 
  • Builds strength: Exercise strengthens muscles, which support joints and can help prevent further pain and injury. 

 

    Tips for exercising safely with pain:

  • Consult your doctor: Get a proper diagnosis and clearance from a healthcare professional before starting. 
  • Start slowly: Gradually increase the intensity and duration of your workouts to allow your body to adapt. 
  • Listen to your body: Pay attention to pain signals and scale back if you experience significant soreness or pain. 
  • Choose appropriate activities: Opt initially for low-impact exercises like walking, swimming, or gentle stretching that are suited to your condition and progress into more advanced exercises as symptoms allow. 
  • Incorporate movement into your day: Break up periods of sitting by standing and moving around. 
  • Consider support: Exercising with a friend or in a group can provide motivation and support. 

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Did I do something wrong to cause my pain?

     Blaming yourself for your persistent pain symptoms is common, but reality is, it's not your fault. In very rare cases people engage in self-harm or self-abuse due to other underlying behavioral contributors, but this is uncommon. Questioning our past behaviors or choices is sometimes one of the most challenging obstacles for people recovering from persistent pain. We can't go back in time to relive past events and fixate on how things could have been better if we had just done things a bit differently. Whether it was a mistake we feel we made, or something someone else did, holding on to these thoughts will invariably hold back our recovery. We only have control over this moment - the past is the past and the future is yet to be determined. Focusing our efforts on the right now is the first step in paving a new way forward. 

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What treatments should I avoid?

    No single pain treatment can be universally avoided, as appropriateness depends on your specific health conditions, pain type, and other medications. However, certain treatments carry significant risks and are often advised against for long-term or widespread use, especially for older adults or those with pre-existing health conditions. Always discuss any new treatment with your doctor. 

 

Medications

Opioids - Opioid medications can be highly effective for severe, short-term pain, such as after surgery. However, due to their significant risks, they are not recommended for most patients with chronic, non-cancer pain and should be used with extreme caution. 

Risks of opioids: 

  • Dependence and addiction (Opioid Use Disorder): With long-term use, the body can become physically dependent on opioids, leading to withdrawal symptoms and a high potential for addiction.
  • Overdose and death: Opioids can slow or stop breathing, which can be fatal. This risk increases with higher doses and when combined with other substances like alcohol or benzodiazepines.
  • Increased pain sensitivity (Hyperalgesia): Paradoxically, long-term opioid use can make a person more sensitive to pain.
  • Long-term side effects: These include chronic constipation, depression, and hormonal changes that can affect libido and energy levels. 

 

Nonsteroidal anti-inflammatory drugs (NSAIDs) - While often used for pain and inflammation, long-term or high-dose use of oral NSAIDs like ibuprofen and naproxen carries serious risks, especially for certain populations. 

Risks of NSAIDs: 

  • Cardiovascular issues: NSAIDs can increase blood pressure, fluid retention, and the risk of heart attack and stroke. This is a significant concern for older adults and individuals with heart disease.
  • Gastrointestinal damage: NSAIDs can cause stomach pain, ulcers, and bleeding. This risk is higher for those with a history of stomach ulcers, older adults, and people taking blood thinners.
  • Kidney problems: Long-term use can harm the kidneys, especially in older adults and people with pre-existing kidney disease, heart failure, or diabetes.
  • Drug interactions: NSAIDs can interact with blood thinners and other medications, increasing the risk of bleeding. 

 

Certain compounded topical pain creams - The FDA has warned consumers to avoid some compounded topical pain relief products containing dangerous combinations of ingredients, such as lidocaine, prilocaine, and tetracaine. 

Risks of these creams: 

  • Serious side effects: Applying these products over large areas, on broken skin, or wrapping the area with a dressing can lead to dangerously high absorption of the ingredients, causing severe side effects.
  • Dangerous combinations: Products containing more than 4% lidocaine are considered unsafe for widespread use. 

 

Procedural and alternative treatments

Chiropractic adjustments - Many people find relief from chiropractic care, but certain conditions are considered contraindications where adjustments should be avoided. 

Contraindications for chiropractic care: 

  • Severe osteoporosis: Adjustments can increase the risk of fractures due to fragile bones.
  • Certain cancers: Tumors in or near the spine can create complications.
  • Infections: Bone or spinal infections, such as osteomyelitis, make adjustments unsafe.
  • Acute trauma: Manipulations should be avoided in cases of acute fractures, dislocations, or other severe spinal instability.
  • Neurological symptoms: Numbness, tingling, or loss of strength in a limb should be thoroughly evaluated before adjustments. 

 

Massage therapy - Massage therapy is generally safe, but there are certain situations where it should be avoided, at least on a specific area of the body. 

Contraindications for massage therapy: 

  • Deep vein thrombosis (DVT): Massaging can dislodge a blood clot, potentially leading to a life-threatening pulmonary embolism.
  • Fever or infectious disease: Massage can spread the infection throughout the body and to others.
  • Active cancer: Discuss any massage with an oncologist, as manipulating a tumor or affecting the lymphatic system can be risky.
  • Open wounds, bruises, and skin infections: To avoid infection and irritation, massage therapists should avoid massaging directly over these areas.
  • Blood thinners: Individuals on anticoagulant medications are more prone to bruising from massage. 

 

Unproven and unregulated treatments

Kratom - Kratom is an unregulated herbal substance with opioid-like effects that has been associated with severe risks. 

Risks of kratom: 

  • Addiction and withdrawal: It has a potential for abuse, addiction, and withdrawal symptoms similar to those of opioids.
  • Contamination: The FDA has warned that some kratom products have been contaminated with bacteria like Salmonella and concerning levels of heavy metals.
  • Overdose risk: While studies are ongoing, deaths have been associated with kratom, often when combined with other drugs. 

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Is my pain all in my head?

    The statement "pain is all in your head" is a common misconception that can be harmful. 

Explanation: Pain is a complex experience that involves both the brain and the body. When there is actual or potential harm to a body tissue (mechanical, chemical or thermal) it is detected by nociceptors which transmit this information to the thalamus, which is structure deep within the brain. Your brain must determine if this information is 1) credible and 2) useful to help protect you. If the brain determines, based on all other available information (what you see, hear, smell, taste, etc., and what you know about your current environment, any memories that your brain feels are relevant to your current situation) the it will produce the feeling of pain (watch this video here to learn more). However, the brain is not just a passive receiver of pain signals. It can also influence the intensity and duration of pain. Factors such as emotions, expectations, and past experiences can all play a role in how we perceive and experience pain.  Therefore, while the brain is involved in the experience of pain, it is not the sole source of pain. Pain can be caused by physical injuries, as well as by psychological factors. It is important to seek medical attention if you are experiencing persistent or severe pain to determine the underlying cause and receive appropriate treatment. 

 

Conclusion: Pain is not "all in your head." It is a complex experience that involves both the brain and the body. While the brain plays a role in interpreting sensory information from the world inside and outside of your body, it is not the only factor that contributes to the feeling of pain. It is essential to avoid stigmatizing or dismissing people who experience pain by understanding the scientific basis behind it. 

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Will surgery help my pain?

  Surgery can help with certain types of chronic pain by fixing an underlying structural problem, such as severe nerve pain or weakness related to a herniated disc, spinal tumor, or severe spinal stenosis (narrowing of the canal where the nerve travels), but it is not a solution for all pain and should be considered a last resort after non-surgical options like physical therapy and medication have failed. A surgeon will only recommend the procedure if the benefits clearly outweigh the risks, and you will need a definitive diagnosis and a clear understanding of how surgery can correct the specific issue. 

 

    When Surgery Might Help:

  • Structural Problems: Surgery can be effective for pain caused by identifiable structural issues that can be corrected or repaired, such as a herniated disc, a tumor, or a spinal fracture. 
  • Nerve Damage: If your pain is due to peripheral nerve damage or a nerve being severely compressed, surgery to decompress the nerve might provide relief. 
  • Failed Non-Surgical Treatments: Surgery is often considered only after more conservative treatments, such as medications, physical therapy, and injections, have not provided significant relief for chronic pain. Keep in mind, just because other treatments have not provided relief, it doesn't mean surgery will either. Unfortunately, in some cases, it may actually worsen symptoms. 

 

    When Surgery May Not Help:

  • General Chronic Pain: Surgery rarely helps with chronic pain that doesn't have a specific, treatable structural problem. 
  • Worsening Pain:  In some cases, surgery can even make the pain worse than it was before. 
  • Underlying Health Conditions: If you have other uncontrolled health conditions, the risks associated with surgery may make it an unsuitable option. 

 

    Next Steps:

  • Consult a Pain Specialist with experience working in an interdisciplinary program: Before considering surgery, see a pain management specialist to get a proper evaluation and discuss all your treatment options.
  • Get a Definitive Diagnosis: A clear diagnosis is essential to determine if a surgical solution is appropriate for your specific condition.
  • Discuss Risks and Benefits: A surgeon will outline the potential risks and benefits of surgery and compare them to non-surgical alternatives to help you make an informed decision. 

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How do I communicate my pain to my doctor?

   To effectively communicate your pain to a doctor, create a detailed pain journal to track when and where the pain occurs, its characteristics (sharp, dull, throbbing), intensity on a 1-10 scale, triggers, and how it affects daily activities. Be specific with your descriptions, using body landmarks and descriptive words, and be honest about pain's impact on your life. Organize your thoughts and questions before the appointment to ensure clear, concise communication, and feel empowered to self-advocate by asking questions or seeking a second opinion. 

 

Before Your Appointment

Keep a Pain Journal:

Track Symptoms: Record the date, time, location, and type of pain.

Note Triggers: Document what activities, situations, or foods make the pain worse or better.

Monitor Duration and Frequency: Keep track of how long the pain lasts and how often it occurs.

Use a 1-10 Pain Scale: Assign a number to rate the intensity of your pain, noting how it fluctuates throughout the day.

Prepare Your Thoughts:

List Symptoms: Write down specific symptoms, patterns, and any changes you've noticed.

Formulate Questions: Think of questions about your condition and potential treatment options to ask during the appointment. 

 

During Your Appointment

Be Specific and Detailed:

Location: Pinpoint the exact area of pain, noting if it spreads to other parts of your body.

Character: Use descriptive words like aching, burning, sharp, shooting, or throbbing to explain the pain's quality.

Intensity: Use the 1-10 scale to describe severity, providing context for when pain is mild or severe.

Triggers and Relievers: Explain what makes the pain worse or better, such as certain movements or rest.

Describe the Functional Impact:

Connect to Daily Life: Explain how the pain affects your ability to perform daily tasks, work, sleep, and socialize.

Use Tangible Examples: Instead of saying, "I can't do much," describe specific activities you've had to stop doing, like cooking or walking.

Self-Advocate:

Ask Questions: Don't hesitate to ask for clarification if you don't understand something or feel your concerns aren't being addressed.

Express Concerns: Speak up if you feel misunderstood, dismissed, or if a treatment isn't working.

Request a Specialist or Second Opinion: If you feel your needs aren't being met, ask for a referral to a specialist or seek a second opinion. 

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Will persistent pain affect my mental health?

   Yes, chronic pain significantly affects mental health and is strongly linked to higher rates of depression and anxiety, with some studies finding people with chronic pain are four times more likely to have these conditions than those without pain. This relationship is bidirectional, meaning mental health issues can also worsen pain, due to shared biological mechanisms, the constant stress of pain, and disruption to daily life, sleep, and social activities. 

 

How Chronic Pain Impacts Mental Health

  • Anxiety: The fear of pain returning can create a state of hyper-vigilance, making it difficult to relax and increasing anxiety. 
  • Depression: The physical limitations, sleep disturbances, fatigue, and loss of enjoyment from activities can all contribute to feelings of depression. 
  • Substance use disorders: Chronic pain can increase the risk for substance use problems as people may try to cope with their pain. 
  • Reduced quality of life: The combined physical and psychological toll of chronic pain can lead to a significant decrease in overall quality of life. 
  • Emotional distress: The constant, unrelenting nature of chronic pain can lead to feelings of sadness, frustration, anger, and demoralization. 

 

The Bidirectional Relationship

  • Shared neural mechanisms: Research suggests that mental health conditions and chronic pain share similar biological pathways in the brain, contributing to their interconnectedness. 
  • Psychological factors influence pain: Factors like stress, mood, and perceptions of pain can influence how intensely pain is experienced. 

 

What Can Be Done

  • Integrated treatments: Managing chronic pain often involves both physical treatments and psychological support, such as cognitive-behavioral therapy (CBT). 
  • Mindfulness and relaxation: Techniques like mindfulness and meditation can help manage stress and alter pain perception. 
  • Seek professional help: It's important to talk to a healthcare provider or mental health professional if you are experiencing consistent emotional responses or difficulty functioning due to chronic pain. 

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How do I support someone with persistent pain?

    When supporting someone with chronic pain, here are some ways a loved one can help:

  • Understand the nature of chronic pain.
  • Encourage movement and physical activity.
  • Support a balanced routine.
  • Provide emotional support.
  • Avoid enabling behaviors.
  • Stay informed and advocate for proper medical care.
  • Encourage self-care.

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What is a pain flare, and how do I manage it?

    A flare-up is a temporary and often sudden increase in the severity of symptoms, such as pain, swelling, or fatigue, that occurs in someone with a chronic or long-term condition. These flares are periods of worsening symptoms, but they are typically not a sign of a new illness or that the underlying condition has permanently worsened. Flares can be triggered by various factors, including stress, overexertion, illness, or even unpredictable changes in the body.  

 

Common characteristics of a flare-up

Short duration: 

While flares can last for hours, days, or weeks, they are generally a temporary phase, and the condition will improve again. 

Triggers: 

Flares can be brought on by physical factors like overexertion, illness, or lack of sleep, as well as mental factors such as stress or emotional upset. 

Unpredictable: 

Flares can come on quickly and without much warning. 

Not a new condition: 

A flare-up is an intensification of your existing chronic condition, not the onset of a new one. 

Temporary worsening of symptoms: 

You may experience increased pain, fatigue, swelling, or other typical symptoms of your condition. 

 

Examples of chronic conditions with flares

Arthritis: Conditions like juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA) involve periods of increased joint pain, swelling, and stiffness. 

Fibromyalgia: This condition involves fluctuating levels of chronic pain, tenderness, and fatigue, with periods of intense symptoms. 

Lupus: A chronic autoimmune disease that can cause a range of symptoms, including fatigue and pain, that can suddenly worsen during a flare. 

Cancer: Patients with cancer may experience a sudden increase in pain, known as a pain flare or breakthrough pain, which is typically short-lived. 

To manage a pain flare-up, apply gentle heat or cold to the affected area, engage in light movement and stretching to maintain flexibility, practice relaxation techniques like deep breathing and meditation, and use distraction to take your mind off the pain. It's also crucial to pace yourself, get adequate rest and sleep, maintain a healthy diet, and consider adjusting medication as needed, all while keeping an activity diary to identify triggers and successful strategies for future reference. 

 

Immediate Relief Strategies

  • Heat and Cold Therapy: Apply a warm bath, shower, or heat pad to relax tense muscles and improve circulation, or use cold therapy to reduce inflammation and numb pain. 
  • Gentle Movement: While avoiding complete immobility, gentle stretching and movement can help maintain flexibility and prevent stiffness. 
  • Relaxation Techniques: Deep breathing exercises, meditation, and taking a warm bath can help relax your body and calm the nervous system. 
  • Pacing and Activity Management
  • Pace Your Activities: Cut back on physical activities but don't stop completely. Pacing prevents overactivity and underactivity, which can worsen a flare-up. 
  • Set Realistic Goals: During a flare-up, focus on small, achievable goals to build momentum and maintain a sense of progress. 

 

Mindset and Emotional Well-being

  • Practice Positive Thinking: Focus on what you can do and remind yourself that the flare-up is temporary. 
  • Distraction: Engage in fun hobbies, read, listen to music, or watch a movie to redirect your focus away from the pain. 
  • Stay Connected: Talk to a trusted friend, partner, or family member, as they may notice potential triggers that you've overlooked. 

 

Long-Term Flare Management

  • Create an Activity Diary: Track your activities, pain levels, and mood to identify your personal triggers and learn what strategies are most effective for you. 
  • Plan for the Future: Keep a "flare box" with useful items, such as your favorite book or a list of comforting activities, to help you cope when the next flare-up occurs. 
  • Consult a Professional: Discuss your flare-up management plan, including medication adjustments, with your doctor or healthcare professional in advance. 

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How do I know if my pain is dangerous?

    (Credit: Franciscan Health) We're all familiar with physical pain and discomfort. Pain can be defined as a signal throughout your nervous system that indicates something could be wrong in your body. While each person may experience different levels of pain in multiple areas of their body depending on their condition, pain sensations can include a prick, burn, sting, ache or even a tingle.

    Even though acute pains can go as quickly as they show up, chronic pain can take much longer to go away or may not leave at all until the cause of the pain is solved. Regardless, it's wise to pay attention to your pain so it can be addressed before your pain causes more health problems.

"People have to make a judgment call for themselves, whether they're going to go to an emergency room or make an appointment with their doctor," says Robert Hockberger, MD, chair of emergency medicine at Harbor-UCLA Medical Center in Los Angeles. Paying close attention to pain can make that call easier to make. It could even save your life."

    Of course, you shouldn't worry about every ache and twinge. Dr. Hockberger offers some general rules of thumb to separate run-of-the-mill pain from the kind that could signal a serious medical problem. "We ask patients to rate their pain from a one to a 10," he said. "People who feel that their pain is a seven or higher - anything worse than a bad toothache - should see a doctor right away." According to Dr. Hockberger, you should also see a doctor if you have moderate pain that doesn't go away within a few days, or if any treatment that previously relieved pain suddenly stops working. You'll be way ahead in the guessing game if you familiarize yourself with some serious conditions that cause pain. This list is by no means definitive -- a roster of every painful malady could fill a medical book, and probably has -- but it's a good place to start. If you're alert to these problems, you're likely to get the help you need.

 

Leg Pain With Swelling

Symptoms -  One of your legs suddenly becomes painful and swollen. The pain is especially noticeable when you stand or walk around. The swollen area -- most likely a calf or thigh -- may be red or warm.

 

What Your Leg Pain Could Be

Leg pain with swelling can be a sign of deep vein thrombosis, a blood clot forming in a vein deep within the leg. These blood clots are dangerous because they can break free and move to the lungs, causing a pulmonary embolism. Deep vein thrombosis most often occurs when a person isn't moving enough to keep blood flowing briskly through the legs. The condition is sometimes called "economy class syndrome," because it can strike during a long plane ride. People stuck in hospital beds are also at risk for deep vein thrombosis, as are people ages 60 or older, women taking birth control pills, women who have recently given birth, and anyone who is overweight.

 

What You Should Do About Your Leg Pain

If you are experiencing leg pain with swelling, make an appointment to see a doctor immediately. Be sure to tell your doctor if you've just finished a long trip or if there is any other reason to suspect a blood clot. Prompt treatment can clear the blood clot before it has a chance to cause trouble.

 

Sudden Testicular Pain

Symptoms - As unpleasant as it may be, imagine a swift kick to the groin. The pain, possibly along with swelling, will be on one side of the scrotum. This isn't just a dull ache. It's the type of pain that makes it difficult to walk or even talk.

 

What Your Testicular Pain Could Be

Sudden testicular pain can be a sign of testicular torsion. In this condition, the cord that connects to the testicles becomes twisted, cutting off blood flow. Other possible (but rare) reasons of sudden testicular pain include testicular cancer and epididymitis, an infection of a small organ on the testicle. However, infections of the testicle tend to come on much more gradually and aren't nearly as painful.

 

What You Should Do About Your Testicular Pain

If you experience sudden testicular pain, get to a doctor immediately. If you do have testicular torsion, it's an emergency, because the testicle will become damaged without adequate blood flow.

 

Painful Urination

Symptoms - You feel pain or a burning sensation when urinating. You may also have frequent urges to urinate without results.

 

What Your Painful Urination Could Be

Painful urination may mean you have an annoying but harmless urinary tract infection (UTI), but in very rare cases painful urination could be a sign of something serious, like a sexually transmitted disease or, much more rarely, bladder cancer. (The classic sign of bladder cancer is the painless passing of blood in the urine.) Although UTIs are especially common in women, men are three to four times more likely than women to get bladder cancer.

 

What You Should Do About Your Painful Urination

If you experience painful urination, schedule an appointment with your doctor or urologist. If it's nothing serious, treatment can quickly relieve the pain. If it is bladder cancer, prompt diagnosis can increase your chances of recovery.

 

Sudden Chest Pain

Symptoms - You suddenly feel unusual pain, discomfort, or pressure in the center of your chest. The feelings may linger for more than a few minutes, or they may disappear and come back. The pain and discomfort in your chest can spread to one or both arms or to the neck, jaw, stomach, or back. Other possible symptoms include shortness of breath, nausea, lightheadedness, or a cold sweat.

 

What Your Sudden Chest Pain Could Be

Sudden chest pain may be caused by a pulmonary embolism (obstruction of a blood vessel by a clot or other matter), pneumothorax (too much air or gas in the chest cavity), or a bout of angina (chest pain caused by inadequate blood flow). You might also be having a heart attack.

Be aware that most heart attacks start much more slowly than the Hollywood variety - you're more likely to feel a dull or vague pressure in the chest than a sharp pain. Some heart attacks are so subtle that it can be hard to tell then apart from simple indigestion or heartburn, Hockberger says. In many cases, it takes an EKG or other hospital test to tell the difference.

 

What You Should Do About Your Sudden Chest Pain

If you experience sudden chest pain and think you might be having a heart attack or another medical emergency, don't wait any longer than five minutes to call 911 or get to a hospital. If you are having a heart attack or embolism, waiting too long to get help could be a fatal mistake.

 

Severe Headache

Symptoms - Picture your worst headache -- even a skull-splitting migraine -- and imagine turning it up several notches. This mega-headache can strike suddenly, "like a thunderclap," Hockberger says. Other possible symptoms include double vision, nausea, vomiting, and a stiff neck.

 

What Your Severe Headache Could Be

A severe headache could be just a bad migraine, but it could also be a ruptured aneurysm, bleeding in the brain that occurs when a weak spot in a blood vessel suddenly bursts. While migraines can cause similar symptoms, Hockberger notes that most people with migraines have their first episode before they turn 25. Doctors hear alarm bells when a person over 25 has the first killer headache of his or her life. Every year, about 30,000 people in this country develop ruptured aneurysms. According to a report from Johns Hopkins Medical Institute, half of all ruptured aneurysms cause sudden death, but over 80 percent of patients who can make it to the hospital survive. Anyone of any age can suffer a ruptured aneurysm, but they are more common in adults than in children. Smokers, people with hypertension, and people who abuse alcohol or illegal drugs are at especially high risk.

 

What You Should Do About Your Severe Headache

Call 911 or get to an emergency room right away.

 

A Stiff Neck Accompanied By Fever And/Or A Severe Headache

Symptoms -  Many different things can cause sudden pain or stiffness in the neck. But if your neck pain or stiffness is accompanied by either a fever or a severe headache or both (often with sensitivity to light), you could be facing an emergency.

 

What A Stiff Neck With A Fever Or Severe Headache Could Be

A stiff neck with a fever or severe headache could be a sign of meningitis, an infection of the membrane that surrounds the brain. While meningitis can be caused by either viruses or bacteria, the bacterial kind is far more dangerous and potentially deadly. Bacterial meningitis comes on quickly - you may feel perfectly fine one day and deathly ill the next. The condition can cause vomiting, nausea, and a rash along with behavioral changes such as confusion and sleepiness.

 

What You Should Do

Call 911 or get to an emergency room right away.

 

Sudden, Sharp Pain In The Abdomen

Symptoms - You have pain that starts at the center of the abdomen, usually in the area around the belly button. It eventually becomes more severe and shifts to the lower right side of the belly, making it painful to the touch. You may have nausea, vomiting, a low-grade fever (under 100 degrees) diarrhea, constipation, inability to pass gas, swelling in the abdomen and a lack of appetite. Eventually, the abdominal pain may become so sharp or painful that it hurts to move. You may even feel like someone has put a knife or a bullet in your guts -- from the inside.

 

What A Sharp Pain In The Abdomen Could Be

Sharp pain in the abdomen may a sign of appendicitis - inflammation of the appendix - a common emergency that's easy to dismiss as "just another stomachache." Ignoring the pain is dangerous, because an inflamed appendix could burst without prompt treatment. Sharp abdominal pain could also be a symptom of an inflamed gallbladder or pancreas. Just like an inflamed appendix, the gallbladder can rupture if it is not treated right away. An inflamed pancreas also needs prompt medical attention. Finally, if you are female, you may have an inflamed ovarian cyst, a pelvic infection, or, if you're of childbearing age, an ectopic pregnancy.

 

What You Should Do About A Sharp Pain In Your Abdomen

If you think you may have appendicitis, an inflamed gallbladder, or an ectopic pregnancy, get to a hospital quickly. An ectopic pregnancy can be life-threatening, and if your appendix really is inflamed, it needs to be removed before it causes serious problems. Every year, about 260,000 people in the United States have surgery to remove a troublesome appendix. If you suspect you have a pelvic infection such as pelvic inflammatory disease, seek medical attention quickly - without treatment, this can cause permanent scarring, sterility, and in rare cases, a dangerous abscess.

 

Severe Back Pain

Symptoms - Back pain usually goes away on its own, with or without a doctor's help. But if the back pain is sudden, agonizing, and unrelated to exercise or improper lifting, or if you feel excruciating, highly focused pain on your spine, you may be in the midst of an emergency.

 

What Severe Back Pain Could Be

Sudden, severe back pain may signal a kidney stone or an abdominal aneurysm, a bulge in the main artery leading from the heart. Kidney stones blocking the flow of urine tend to cause sharp or cramping pain that starts in the back or side and moves to the groin. Abdominal aneurysms, most common in older people with atherosclerosis, may produce only mild pain as the bulge grows. The pain suddenly becomes excruciating if the aneurysm bursts.

Intense, pinpoint pain may be a sign of an infection beneath the membrane that covers the spinal cord. This condition, called an epidural abscess, strikes about 10,000 people each year. If not treated promptly, it can cause paralysis of the lower part of the body, sometimes in just a few hours. Epidural abscesses often come on the heels of minor infections, such as infections of the sinuses or urinary tract. People with diabetes and IV drug users are most at risk.

 

What You Should Do About Your Severe Back Pain

Call 911 or get to an emergency room right away.

 

Nagging Foot Or Shin Pain

Symptoms - Your normally full exercise schedule is slowed down by persistent pain on the top of your foot or the front of your lower leg. The pain builds gradually, gets worse when you put weight on your leg, and fades when you rest. If the pain is on the top of your foot, you might also notice swelling on the sore spot.

 

What Nagging Foot Or Shin Pain Could Be

Nagging foot or shin pain could be a sign of a stress fracture - a hairline crack in the bone. Stress fractures are common "overuse" injuries, often striking athletes in sports that give the feet a pounding, including track, basketball, and tennis. Adolescents and women with unusual or absent menstrual cycles are especially at risk for stress fractures.

 

What You Should Do About Your Foot Or Shin Pain

Foot or shin pain isn't a medical emergency, but it's one time when you don't want to play through the pain. Schedule an appointment with your doctor or orthopedist to get a diagnosis. If you have a stress fracture, you'll need to take it easy for a couple of weeks to let your bone heal. Pain is an imperfect guide to illness. Some conditions are painful but not dangerous, while other very serious conditions may strike with no pain at all. If you do have questions about a pain you have, it's best to consult your doctor. There can be several reasons for your pain and it's crucial to pay attention to avoid your condition from getting worse over time. While, at times, you may have an ache from exercising without stretching beforehand, other sudden surges of pain that tend to stick around may be worth getting professionally examined. Even though this guide may give some insight into the pain you might feel, the next step is to stay in contact with your primary care provider for consistent checkups and know the location of the nearest emergency room.

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What if I no longer have access to opioids?

(Credit: HSS) Treating acute pain caused by orthopedic surgery has improved drastically over the past few years. This is due in part to the use of multimodal analgesic strategies (balancing opioid pain medications with the use of non-opioid options targeting surgical, muscular and neuropathic pain) and an increase in regional anesthesia in orthopedic procedures.

    Patients may be prescribed a short dose of opioid therapy to help manage short-term pain caused by surgery. For patients who may require more extensive or high-dose opioid use, or who have a history of opioid use, tapering (gradual reduction) is a vital part of the healing process. Patients who may benefit from tapering off their opioid regimens should do so under the management of a physician.

 

 

Prescription opioids include but are not limited to the following:

  • codeine
  • fentanyl (also known as fentanil)
  • hydrocodone (Vicodin, Norco and others)
  • hydromorphone (Dilaudid)
  • methadone
  • morphine
  • oxycodone (Percocet, OxyContin and others)
  • tramadol (Ultram)

 

Why should patients taper opioid use?

    While opioids remain a significant and essential part of some patients’ healing requirements, opioid use needs to be tailored to each individual and their postsurgical pain levels.

    There are many effects linked to long-term opioid use which patients should consider:

  • Opioid-Induced hyperalgesia (abnormal pain sensitivity from long term opioid use).
  • Physical dependence (if used long term, opioids can cause withdrawal symptoms when abruptly stopped).
  • Constipation and nausea.
  • Drowsiness and fatigue, which can lead to increased falls and broken bones.
  • Depressed mood, which can lead to low energy, poor appetite, poor sleep, and decreased activity.
  • Sleep apnea, which can lead to increased daytime fatigue and other health complications.
  • Lowered testosterone in men, which can lead to lower sex drive, osteoporosis, depressed mood and loss of muscle.
  • Low estrogen in women, which can lead to osteoporosis, low energy, and change in menstruation.
  • Respiratory health issues.

    Patients who are already using opioids to treat their pain before coming into surgery tend to require much higher doses of opioids after surgery. This puts them at a higher risk of developing opioid-related side effects and may lead to longer hospital stays or even negatively influence their surgical outcomes.

Some patients may feel withdrawal symptoms if they taper off of opioids too quickly, depending on their history of opioid use and their pain. While these symptoms can be uncomfortable, they are generally not life-threatening.

 

Withdrawal symptoms may include:

  • Flu-like symptoms (sweating, chills, goose bumps, headache, generalized muscle and/or joint aches).
  • Fatigue, restlessness, anxiety, trouble sleeping, hallucination and/or tremors.
  • Nausea, vomiting, abdominal cramps and/or diarrhea.
  • Increased heart rate and blood pressure (which may also feel like a headache).
  • Withdrawal symptoms typically start 12 to 48 hours after the last dose of opioids. Usually, it is during the 24- to 96-hour period after stopping opioids that the worst of these symptoms occur. They will then improve from between 5 to 7 days after the last opioid dose. For some patients, withdrawal may last longer. Some patients that have been on high-dose opioids may experience generalized tiredness or feel unwell for a few weeks.

 

How does long-term opioid use affect tapering?

    Patients who have been taking opioids long-term (more than six months) should discuss with their physician their desire to decrease their opioid use. Physicians and patients should work together to develop a treatment plan to manage withdrawal symptoms. Fast tapering is the process of stopping all opioids or reducing opioids quickly over a few days to a week, decreasing the total daily dose by 20% to 25% every few days to minimize withdrawal symptoms. Shorter intervals of time or higher percentage decreases of opiod doses will usually cause severe withdrawal symptoms. Most physicians typically recommend close monitoring and/or supervised centers for patients considering a fast tapering program.

    Slow tapering is the process of decreasing total daily opioid doses by 10% to 25% every 1 to 3 weeks with close follow-up with a physician. Depending on the patient’s use prior to starting the slow taper, dose of an opioid may be decreased first before increasing the time interval between doses. Once patients are on the lowest dose of an opioid, they will then be asked to decrease the frequency of use and leaving the nighttime dose as the last dose before stopping completely.

 

 

What are nonpharmacologic techniques for minimizing withdrawal symptoms?

  • Stay hydrated by drinking plenty of water.
  • Eat regularly and choose healthy meals.
  • Stay active with moderate exercise, including walking, stretching and deep-breathing exercises.
  • Use relaxation techniques, which can include breathing exercises, music therapy, guided imagery, meditation and reading.
  • Keep a positive outlook and surround yourself with people to keep your moo.d positive.
  • Do not substitute alcohol or other substances to help with tapering down.

    

    It is vital for patients, caregivers, and physicians to be vigilant about opioid use and the process of tapering off of these medications. This article should not be viewed as medical advice. As with all medical regimens, patients should consult and work with their physician before tapering their prescription opioid use.

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Are there any promising treatments for my pain?

    Promising pain treatments include novel non-opioid medications like suzetrigine (Journavx) for acute pain, ketamine therapy and low-dose naltrexone (LDN) for chronic pain, and neuromodulation techniques such as spinal cord stimulation. Other promising approaches involve plant-derived compounds, like RTX, which targets specific nerve fibers to block pain signals, and the use of endogenous pain modulators. These treatments aim to provide effective pain relief with fewer side effects and risks of addiction compared to traditional opioids. 

 

Novel and Emerging Medications

  • Suzetrigine (Journavx™): A new non-opioid prescription medication approved for moderate-to-severe acute pain. It works by blocking pain impulses at the source of the pain, reducing the risk of addiction. 
  • Cebranopadol: An experimental medication with a dual mechanism of action that shows potential to effectively treat moderate-to-severe pain with a minimized risk of addiction or respiratory depression compared to opioids. 
  • Ketamine Therapy: Uses NMDA receptor modulation to recalibrate pain signals, offering rapid and effective pain relief as an alternative to opioids. 
  • Low-Dose Naltrexone (LDN): An opioid-receptor antagonist that shows promise as a broad-spectrum analgesic for chronic pain. 

 

Neuromodulation Techniques

  • Spinal Cord Stimulation (SCS): A technique that uses electrical impulses to alter pain signals sent to the brain, often used for chronic pain conditions. 
  • Other Neuromodulation Methods: A range of other techniques that aim to change how pain signals are processed and perceived by the nervous system. 

 

Targeted Nerve Therapies 

  • RTX (Resiniferatoxin): A plant-derived compound that activates TRPV1 channels in nerve fibers, causing a calcium overload that inactivates the nerve's ability to transmit pain, heat, and other signals. 
     

Other Approaches

  • Manual Therapy: A conservative treatment that can help patients recover without the use of pain-killers or surgery. 
  • Anticonvulsants and Antidepressants: These medications have shown success in treating neuropathic pain by controlling pain, depression, and mood disorders. 
  • Nonpharmacological Therapies: A combination of exercise, mind-body interventions, and behavioral treatments like mindfulness and cognitive behavioral therapy (CBT) encourage active patient involvement in pain management. 

 

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